Identifying haplotype block structure using an ancestor-derived model
نویسندگان
چکیده
منابع مشابه
Identifying haplotype block structure by using ancestor-derived model
Recently, haplotype-based association studies have become popular for detecting disease-related or drug-response-associated genes. In these studies, it has been gradually recognized that a haplotype block structure is important. A rational and automatic method for identifying the haplotype block structure from SNP data has been desirable. We have developed a new method by using an ancestor-deri...
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In this report, we examine the validity of the haplotype block concept by comparing block decompositions derived from public data sets by variants of several leading methods of block detection. We first develop a statistical method for assessing the concordance of two block decompositions. We then assess the robustness of inferred haplotype blocks to the specific detection method chosen, to arb...
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Genetic variation in genomes is organized in haplotype blocks, and species-specific block structure is defined by differential contribution of population history effects in combination with mutation and recombination events. Haplotype maps characterize the common patterns of linkage disequilibrium in populations and have important applications in the design and interpretation of genetic experim...
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چکیده ندارد.
Haplotype Block Detection Using Cira Pattern Discovery
This note reports on a novel method of detection of haplotype blocks in the human genome. It is based upon pattern discovery using technology being patented by Cira Discovery Sciences, Inc. It is intended as a demonstration of our pattern discovery technology in the context of genomic variation (SNP) data. Actual applications in genomic analyses will take advantage of technological advances tha...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2007
ISSN: 1434-5161,1435-232X
DOI: 10.1007/s10038-007-0176-8